clustalx uses libXm.so.1 This file is an XMotif library. In earlier Red Hat releases, XMotif was supplied by the lesstif package. Now, a different library is supplied. This brings two problems: First, the generic RedHat install has two broken links in /usr/lib to libXm.so.1 and libXm.so.2. These can be fixed by adding a link to libXm.so in /usr/X11R6/lib. lrwxrwxrwx 1 root root 23 Jul 6 12:58 /usr/lib/libXm.so -> /usr/X11R6/lib/libXm.so lrwxrwxrwx 1 root root 8 Jul 6 12:50 /usr/lib/libXm.so.1 -> libXm.so lrwxrwxrwx 1 root root 8 Jul 6 12:50 /usr/lib/libXm.so.2 -> libXm.so So far so good, but and now both programs find the file, but both end up with segmentation faults I have also tried installing libXm.so.1 and libXm.so.2 individually, from the lesstif-0.93.91.91-1, which should be the most recent version. With these files, the programs run, but again, but the interface looks a bit different (eg. white space where there shouldn't be any) and segmentation faults occur frequently. It looks like there is a compatability issue, I'm guessing with Vibrant. The fix for clustalx is to include libXm.so.1 in $birch/lib-linux-intel. If you need further information I'll try to answer your questions.